Kirstilä V, Sewón L, Laine J
Department of Periodontology, University of Turku, Finland.
J Periodontol. 1993 Jun;64(6):566-70. doi: 10.1902/jop.1993.64.6.566.
The periodontal status and treatment of three teenagers in a Finnish family with familial neutropenia is described. The mother was also diagnosed with neutropenia. At initial examination, the 15-year-old male and the 10-year-old female had severe periodontitis, whereas the 13-year-old male had oral ulcerations but no significant periodontal disease. The two siblings with periodontitis were treated and followed approximately 5 years. It was concluded that periodontal therapy including scaling, surgery, and use of antimicrobial agents can be successful in patients with familial neutropenia, and that such patients are not necessarily candidates for full mouth extraction. The role of granulocyte colony-stimulating factor in which was used in the treatment of these patients remains to be established.
本文描述了芬兰一个患有家族性中性粒细胞减少症的家庭中三名青少年的牙周状况及治疗情况。母亲也被诊断出患有中性粒细胞减少症。初诊时，15岁男性和10岁女性患有严重牙周炎，而13岁男性有口腔溃疡但无明显牙周疾病。对两名患有牙周炎的兄弟姐妹进行了约5年的治疗和随访。得出的结论是，包括洗牙、手术和使用抗菌药物在内的牙周治疗对家族性中性粒细胞减少症患者可能是成功的，而且这类患者不一定需要进行全口拔牙。粒细胞集落刺激因子在这些患者治疗中的作用仍有待确定。
