Bickle T A, Krüger D H
Department of Microbiology, Biozentrum, Basel University, Switzerland.
Microbiol Rev. 1993 Jun;57(2):434-50. doi: 10.1128/mr.57.2.434-450.1993.
Our understanding of the evolution of DNA restriction and modification systems, the control of the expression of the structural genes for the enzymes, and the importance of DNA restriction in the cellular economy has advanced by leaps and bounds in recent years. This review documents these advances for the three major classes of classical restriction and modification systems, describes the discovery of a new class of restriction systems that specifically cut DNA carrying the modification signature of foreign cells, and deals with the mechanisms developed by phages to avoid the restriction systems of their hosts.
近年来，我们对DNA限制与修饰系统的进化、这些酶的结构基因表达调控以及DNA限制在细胞代谢中的重要性的理解有了长足的进步。这篇综述记录了这三类经典限制与修饰系统的进展，描述了一类新的限制系统的发现，这类系统能特异性切割携带外来细胞修饰特征的DNA，并探讨了噬菌体为规避宿主限制系统而形成的机制。
