Hamamci N, Hawran S, Biering-Sørensen F
Centre for Spinal Cord Injured, Rigshospitalet, National University Hospital, Copenhagen, Denmark.
Paraplegia. 1993 Jun;31(6):375-9. doi: 10.1038/sc.1993.62.
The most important complications encountered by achondroplastic dwarfs are neurological problems related to a narrowed spinal canal. Stenosis of the spinal canal is secondary to abnormalities of endochondral ossification with premature synostosis of the ossification centres of the vertebral body and the posterior arch, resulting in thickening of the lamina, shortening of the pedicles, and reduced height of the vertebral bodies. Additional factors such as prolapsed intervertebral discs, osteophytes and progressive thoracolumbar kyphosis contribute to the narrowing of the spinal canal. Three achondroplastic dwarfs having spinal stenosis and spinal cord lesion representing typical clinical courses are described.
软骨发育不全性侏儒所遇到的最重要并发症是与椎管狭窄相关的神经问题。椎管狭窄继发于软骨内骨化异常，椎体和后弓的骨化中心过早融合，导致椎板增厚、椎弓根缩短以及椎体高度降低。其他因素，如椎间盘突出、骨赘和进行性胸腰椎后凸，也会导致椎管狭窄。本文描述了三名患有椎管狭窄和脊髓损伤且代表典型临床病程的软骨发育不全性侏儒。
