[造血祖细胞发育的正负调控：模型与事实]
[Positive and negative controls on hematopoietic progenitor development: models and facts].
作者信息
Panterne B, Hatzfeld A, Zhou Y Q, Li M L, Sansilvestri P, Cardoso A, Lévesque J P, Ginsbourg M, Batard P, Kiselev S
机构信息
Laboratoire CNRS de Biologie Cellulaire et Moléculaire des Facteurs de Croissance, UPR 272, IRSC, Villejuif, France.
出版信息
Nouv Rev Fr Hematol (1978). 1993 Jun;35(3):281-3.
PMID:8337145
Abstract
The stochastic model of stem cell differentiation is in accord with experimental findings but does not explain hematopoietic homeostasis. We discuss how positive and negative controls by cytokines and inhibitors could maintain homeostasis, even though progenitor commitment towards the various hematopoietic lineages may be stochastic.
摘要
干细胞分化的随机模型与实验结果相符，但无法解释造血稳态。我们讨论了细胞因子和抑制剂的正负调控如何维持稳态，尽管祖细胞向各种造血谱系的定向分化可能是随机的。
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