Rain J D, Najean Y
Service de Médecine nucléaire, Hôpital Saint-Louis, Paris.
Presse Med. 1993 May 22;22(18):855-8, 863.
During the last three years 77 patients with myelofibrosis were studied by scintigraphy, using 99m Tc colloids and 111 In transferrin as tracers. Low axial uptake of the colloids, extension of the indium uptake beyond the axis towards the knees and sometimes the ankles and elbows, and splenic indium uptake are valuable diagnostic criteria, particularly useful to exclude myelofibrosis associated with a malignant disorder. The clinical severity of the disease, and in particular the disappearance of a physiologically active bone marrow (indium uptake) can be predicted from isotopic studies. Bone marrow scintigraphy could contribute to the difficult decision of splenectomy.
在过去三年中，我们使用99m锝胶体和111铟转铁蛋白作为示踪剂，通过闪烁扫描法对77例骨髓纤维化患者进行了研究。胶体在脊柱轴位摄取较低、铟摄取超出脊柱轴位向膝部甚至有时向踝部和肘部延伸以及脾脏铟摄取是有价值的诊断标准，对排除与恶性疾病相关的骨髓纤维化尤为有用。疾病的临床严重程度，尤其是生理活性骨髓（铟摄取）的消失可通过同位素研究预测。骨髓闪烁扫描有助于脾切除术这一艰难决策。
