醚磷脂 ilmofosine 的抗利什曼原虫活性。
Antileishmanial activity of the ether phospholipid ilmofosine.
作者信息
Croft S L, Neal R A, Thornton E A, Herrmann D B
机构信息
Department of Medical Parasitology, London School of Hygiene and Tropical Medicine, UK.
出版信息
Trans R Soc Trop Med Hyg. 1993 Mar-Apr;87(2):217-9. doi: 10.1016/0035-9203(93)90499-g.
The ether phospholipid ilmofosine (BM 41.440) was active in vitro against amastigotes of Leishmania donovani and an antimony-resistant line of L. infantum in mouse peritoneal macrophages with ED50 values of 3.7 microM and 3.5 microM respectively. Ilmofosine was also active against L. donovani in BALB/c mice following oral and subcutaneous dosing, with an ED50 value of 10.5 mg/kg x 5 by the oral route.
醚磷脂 ilmofosine（BM 41.440）在体外对杜氏利什曼原虫的无鞭毛体以及婴儿利什曼原虫的一个锑抗性株系具有活性，在小鼠腹腔巨噬细胞中的半数有效剂量（ED50）值分别为3.7微摩尔和3.5微摩尔。Ilmofosine经口服和皮下给药后，对BALB/c小鼠体内的杜氏利什曼原虫也具有活性，口服途径的ED50值为10.5毫克/千克×5。
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