Borody T J, Andrews P, Jankiewicz E, Ferch N, Carroll M
Centre for Digestive Diseases, NSW, Australia.
Am J Gastroenterol. 1993 Aug;88(8):1266-8.
Helicobacter pylori may be difficult to detect in individuals with intestinal metaplasia or atrophic gastritis, even though bacteria may persist in the mucosa in low numbers, maintaining elevated serum H. pylori antibody levels. We report a patient with marked, endoscopically visible gastric mucosal changes and focal changes of histological atrophic gastritis, who was negative for H. pylori on urease test, culture, and histology, but had positive H. pylori serology. When treated with triple therapy and reassessed at 6 months, his H. pylori antibody titer fell to low/negative levels, abnormal mucosa was replaced by a velvety, normal lining, and the previous evidence of histological atrophic gastritis was no longer detectable.
幽门螺杆菌在肠化生或萎缩性胃炎患者中可能难以检测到，尽管细菌可能在黏膜中少量持续存在，使血清幽门螺杆菌抗体水平升高。我们报告了一名患者，其内镜下可见明显的胃黏膜改变及组织学萎缩性胃炎的局灶性改变，该患者尿素酶试验、培养及组织学检查幽门螺杆菌均为阴性，但血清幽门螺杆菌检测呈阳性。经三联疗法治疗6个月后复查，其幽门螺杆菌抗体滴度降至低/阴性水平，异常黏膜被天鹅绒样的正常内膜取代，先前组织学萎缩性胃炎的证据也不再可检测到。
