人乳头瘤病毒（JC）诱发的仓鼠实验性松果体细胞瘤中羟基吲哚-O-甲基转移酶活性的改变

Modification of hydroxyindole-O-methyltransferase activity in experimental pineocytomas induced in hamsters by a human papovavirus (JC).

作者信息

Quay W B, Ma Y H, Varakis J N, ZuRhein G M, Padgett B L, Walker D L

出版信息

J Natl Cancer Inst. 1977 Jan;58(1):123-7. doi: 10.1093/jnci/58.1.123.

DOI:10.1093/jnci/58.1.123

Abstract

Hydroxyindole-O-methyltransferase (HIOMT) (HIOMT) activity was studied and compared in 7 pineal tumors (pineocytomas) induced in vivo in Syrian hamsters after postnatal inoculation with strains of human papovavirus (JC). Levels of tumor HIOMT activity were correlated with degree of cytologic differentiation of the pineocytes of each neoplasm, as judged from electrom micrographs. The relative capacities of the HIOMT in the tumors to methylate three related substrates gave similar ratios in the individual tumors and were not different from those of HIOMT in normal hamster pineal glands.

摘要

对叙利亚仓鼠出生后接种人乳头多瘤空泡病毒（JC）株后体内诱导产生的7个松果体肿瘤（松果细胞瘤）的羟吲哚 - O - 甲基转移酶（HIOMT）活性进行了研究和比较。根据电子显微镜照片判断，肿瘤的HIOMT活性水平与每个肿瘤松果体细胞的细胞学分化程度相关。肿瘤中HIOMT对三种相关底物进行甲基化的相对能力在各个肿瘤中给出了相似的比例，且与正常仓鼠松果体中HIOMT的比例没有差异。

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引用本文的文献

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Experimental and spontaneous pineal tumors: findings relating to endocrine and oncogenic factors and mechanisms.实验性和自发性松果体肿瘤：与内分泌和致癌因素及机制相关的发现

J Neural Transm. 1980;48(1):9-23. doi: 10.1007/BF01670030.

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