Menendez-Pelaez A, Howes K A, Gonzalez-Brito A, Reiter R J
Biochem Biophys Res Commun. 1987 Jun 30;145(3):1231-8. doi: 10.1016/0006-291x(87)91569-5.
The activities of NAT and HIOMT and the melatonin content of the Harderian glands of female Syrian hamsters were studied. When hamsters were kept under a light:dark cycle of 14:10 (lights on at 06.00 h), NAT activity exhibited a sharp, short term rise at one hour after lights on. Simultaneously, the activity of HIOMT, which forms melatonin, exhibited a rapid decline. Melatonin levels, like HIOMT activity, also showed a precipitous drop at one hour after light onset. After the respective changes, both NAT and HIOMT activity reverted back to night time levels. Melatonin levels remained depressed for several hours but by 1400 h (8 hours after lights on), nighttime melatonin values were re-established. Treatment of female hamsters with PCPA, a trytophan hydroxylase inhibitor, led to depressed levels of Harderian melatonin without affecting the activities of either NAT or HIOMT.
对雌性叙利亚仓鼠的哈德氏腺中N - 乙酰基转移酶（NAT）和羟基吲哚 - O - 甲基转移酶（HIOMT）的活性以及褪黑素含量进行了研究。当仓鼠处于14:10的光照：黑暗周期（06:00开灯）时，NAT活性在开灯后1小时出现急剧的短期上升。同时，生成褪黑素的HIOMT活性迅速下降。褪黑素水平与HIOMT活性一样，在光照开始后1小时也急剧下降。在各自发生变化后，NAT和HIOMT活性都恢复到夜间水平。褪黑素水平在数小时内持续降低，但到14:00（开灯后8小时）时，夜间褪黑素值得以重新建立。用色氨酸羟化酶抑制剂对氯苯丙氨酸（PCPA）处理雌性仓鼠，导致哈德氏腺褪黑素水平降低，但不影响NAT或HIOMT的活性。
