Ginsberg S S, Clyne L P, McPhedran P, Duffy T P, Hanson T
Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510.
Br J Haematol. 1993 May;84(1):172-4. doi: 10.1111/j.1365-2141.1993.tb03044.x.
Acquired inhibitors in factor XI deficiency (FXI) are rare. The presence of an inhibitor during pregnancy poses a potential haemorrhagic risk to the fetus. We report an uncomplicated pregnancy and successful childbirth by a woman with congenital FXI deficiency and an acquired inhibitor, and discuss the persistence of residual FXI activity in the presence of an inhibitor.
获得性凝血因子 XI 缺乏症（FXI）中的抑制剂很罕见。孕期存在抑制剂会给胎儿带来潜在的出血风险。我们报告了一名患有先天性 FXI 缺乏症并伴有获得性抑制剂的女性成功妊娠及分娩的病例，并讨论了在存在抑制剂的情况下残余 FXI 活性的持续存在情况。
