Maurea S, Cuocolo A, Pace L, Nicolai E, Nappi A, Imbriaco M, Morisco C, Chiariello M, Trimarco B, Salvatore M
Department of Nuclear Medicine, University Federico II, Napoli, Italy.
Eur J Nucl Med. 1993 Jun;20(6):502-10. doi: 10.1007/BF00175163.
To compare rest-injected thallium-201 (Tl) redistribution and resting technetium-99m methoxyisobutylisonitrile (99mTc-MIBI) myocardial uptake in chronic coronary artery disease (CAD), 15 patients with angiographically proven CAD and left ventricular (LV) dysfunction (ejection fraction 34% +/- 9%) were studied. All patients underwent rest-redistribution Tl and resting 99mTc-MIBI cardiac imaging. Gated 99mTc-MIBI images were also acquired to assess regional LV wall motion (WM). Myocardial segments (n = 225) were divided into three groups on the basis of the degree of coronary artery stenosis: group 1 (total occlusion, n = 82), group 2 (50%-99% of stenosis, n = 84) and group 3 (< 50% of stenosis, n = 59). WM was significantly worse in groups 1 and 2 compared to group 3 (P < 0.001), but no difference was observed between groups 1 and 2. Tl and 99mTc-MIBI uptake were significantly lower in groups 1 and 2 compared to group 3 (P < 0.001), and in group 1 compared to group 2 (P < 0.001). When Tl and 99mTc-MIBI uptake were directly compared. Tl uptake was higher than 99mTc-MIBI uptake in group 1 (P < 0.001), while no significant difference was observed in groups 2 and 3. Thus, both rest-injected Tl redistribution and resting 99mTc-MIBI uptake reflected the severity of coronary artery stenosis in CAD. However, in myocardial segments with total coronary occlusion Tl uptake was significantly higher than 99mTc-MIBI uptake.(ABSTRACT TRUNCATED AT 250 WORDS)
为比较静息注入铊 - 201（Tl）再分布和静息锝 - 99m 甲氧基异丁基异腈（99mTc - MIBI）心肌摄取在慢性冠状动脉疾病（CAD）中的情况，对 15 例经血管造影证实患有 CAD 且左心室（LV）功能障碍（射血分数 34%±9%）的患者进行了研究。所有患者均接受了静息 - 再分布 Tl 和静息 99mTc - MIBI 心脏成像检查。还采集了门控 99mTc - MIBI 图像以评估局部 LV 壁运动（WM）。心肌节段（n = 225）根据冠状动脉狭窄程度分为三组：第 1 组（完全闭塞，n = 82）、第 2 组（50% - 99%狭窄，n = 84）和第 3 组（<50%狭窄，n = 59）。与第 3 组相比，第 1 组和第 2 组的 WM 明显更差（P < 0.001），但第 1 组和第 2 组之间未观察到差异。与第 3 组相比，第 1 组和第 2 组的 Tl 和 99mTc - MIBI 摄取明显更低（P < 0.001），且第 1 组与第 2 组相比也是如此（P < 0.001）。当直接比较 Tl 和 99mTc - MIBI 摄取时，第 1 组中 Tl 摄取高于 99mTc - MIBI 摄取（P < 0.001），而第 2 组和第 3 组中未观察到显著差异。因此，静息注入 Tl 再分布和静息 99mTc - MIBI 摄取均反映了 CAD 中冠状动脉狭窄的严重程度。然而，在冠状动脉完全闭塞的心肌节段中，Tl 摄取明显高于 99mTc - MIBI 摄取。（摘要截短于 250 字）
