Andreose J S, Xu R, Lømo T, Salpeter M M, Fumagalli G
Department of Pharmacology, University of Milano, Italy.
J Neurosci. 1993 Aug;13(8):3433-8. doi: 10.1523/JNEUROSCI.13-08-03433.1993.
The effect of electrical stimulation on the stability of junctional ACh receptors (AChR) on soleus muscles of Wistar rats was compared to that of denervation and reinnervation. Denervation causes the degradation rate of the slowly degrading AChRs (Rs) at the neuromuscular junction to accelerate and be replaced by rapidly degrading AChRs (Rr), while reinnervation restabilizes the accelerated Rs. Electrical stimulation initiated at the time of denervation prevented the acceleration of the Rs. It could not, however, reverse the effect of denervation if initiated after the AChRs became destabilized, nor could it slow the degradation rate of the Rr. We conclude that electrical stimulation of denervated muscle downregulates the expression of the Rr and prevents the destabilization of Rs.
将电刺激对Wistar大鼠比目鱼肌接头型乙酰胆碱受体（AChR）稳定性的影响与去神经支配和再支配的影响进行了比较。去神经支配会导致神经肌肉接头处缓慢降解的AChR（Rs）的降解速率加快，并被快速降解的AChR（Rr）所取代，而再支配则会使加速的Rs重新稳定。在去神经支配时开始的电刺激可防止Rs加速。然而，如果在AChR变得不稳定后开始电刺激，则无法逆转去神经支配的影响，也无法减慢Rr的降解速率。我们得出结论，对去神经支配的肌肉进行电刺激可下调Rr的表达并防止Rs不稳定。
