Butler R W, Copeland D R
Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, New York 10021.
J Pediatr Psychol. 1993 Jun;18(3):319-38. doi: 10.1093/jpepsy/18.3.319.
Reviewed 53 studies on the effects of central nervous system prophylactic treatment (CNSPT) on cognition and neuropsychological functioning. CNSPT involves irradiation and/or chemotherapy directed to the brain, and is frequently administered to children who have leukemia. The effects of CNSPT on neuropsychological functioning in long-term cancer survivors remains controversial. A number of studies failed to identify any neuropsychological impact secondary to CNSPT, whereas others reported deficits that appear to be a function of CNSPT. Several methodological issues that make it difficult to draw meaningful conclusions from this research literature are identified and discussed. Specific recommendations are made for improvements in research on CNSPT in children.
回顾了53项关于中枢神经系统预防性治疗（CNSPT）对认知和神经心理功能影响的研究。CNSPT包括针对脑部的放疗和/或化疗，常用于患有白血病的儿童。CNSPT对长期癌症幸存者神经心理功能的影响仍存在争议。一些研究未能发现CNSPT继发的任何神经心理影响，而其他研究则报告了似乎是CNSPT所致的缺陷。确定并讨论了一些使难以从该研究文献中得出有意义结论的方法学问题。针对改善儿童CNSPT的研究提出了具体建议。
