Nakazawa K, Moriya T, Kasai S, Yamazaki T, Komiyama Y, Shigematsu H, Akiba T, Koga T
Department of Pathology, Shinshu University School of Medicine, Matsumoto, Japan.
Nihon Jinzo Gakkai Shi. 1993 Apr;35(4):329-35.
The effects of Dilazep on immunologically induced glomerular injuries were examined. Accelerated Masugi nephritis in rats produced glomerulosclerosis with proteinuria following administration of a single dose of nephrotoxic serum (NTS). When 5 mg/kg/day of Dilazep had been administered prior to the NTS injection, the proteinuria was resolved rapidly after reaching a maximum level. The glomeruli 3 months later showed significant suppression of glomerulosclerosis and lesser adhesive lesions as compared to those in control rats with Masugi nephritis. On the other hand, when Dilazep was administered from 2 weeks after the injection of NTS, the rats displayed persistent proteinuria and glomerulosclerosis at similar levels to those in the Masugi group. Dilazep appears to exert some protective effects in the early stages of glomerular injuries induced by immunological mechanisms.
研究了地拉卓对免疫诱导的肾小球损伤的影响。给大鼠注射单剂量肾毒性血清（NTS）后会引发加速型马杉肾炎，导致肾小球硬化并伴有蛋白尿。在注射NTS之前给予5mg/kg/天的地拉卓，蛋白尿在达到最高水平后迅速消退。3个月后，与患马杉肾炎的对照大鼠相比，肾小球硬化得到显著抑制，粘连性病变也较少。另一方面，在注射NTS两周后给予地拉卓，大鼠表现出持续蛋白尿和肾小球硬化，程度与马杉组相似。地拉卓似乎在免疫机制诱导的肾小球损伤早期发挥了一定的保护作用。
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