Chow W P, Loganath A, Peh K L, Chew P C, Gunasegaram R, Ratnam S S
University Department of Obstetrics & Gynaecology, National University Hospital, Singapore.
Med J Malaysia. 1993 Mar;48(1):56-63.
This study investigated whether changes in circulating levels of immunoreactive oestradiol-17 beta (E2), progesterone (P) and testosterone (T) occur in women at follicular (n = 18, age 25 to 39 years) and luteal (n = 17, 25 to 39 years) phases of the normal menstrual cycles, experiencing laparoscopy after intravenous sedation with general anaesthesia. The pre- and intra-operative follicular phase plasma steroid hormone concentrations were 153.5 +/- 84.3 vs 297.4 +/- 220.8 pg/ml for E2, 2.0 +/- 3.2 vs 3.3 +/- 3.8 ng/ml for P and 746.6 +/- 415.9 vs 1325.8 +/- 535.1 pg/ml for T, respectively. The corresponding luteal phase steroid levels were 259.7 +/- 120.2 vs 382.7 +/- 188.7 pg/ml, 7.0 +/- 4.8 vs 9.9 +/- 6.1 ng/ml and 819.4 +/- 355.7 vs 1703.5 +/- 1058.1 pg/ml. Using the Wilcoxon rank sum test, intra-operative hormone levels with the exception of P in the luteal phase were found to be significantly elevated (p < 0.05). The results suggest that laparoscopy under general anaesthesia evokes increased secretion of ovarian hormones, possibly via the activation of hypothalamo-pituitary-ovarian axis.
本研究调查了处于正常月经周期卵泡期（n = 18，年龄25至39岁）和黄体期（n = 17，25至39岁）的女性，在静脉镇静联合全身麻醉下接受腹腔镜检查时，其循环中免疫反应性雌二醇 - 17β（E2）、孕酮（P）和睾酮（T）水平是否发生变化。卵泡期术前和术中血浆类固醇激素浓度分别为：E2为153.5±84.3 vs 297.4±220.8 pg/ml，P为2.0±3.2 vs 3.3±3.8 ng/ml，T为746.6±415.9 vs 1325.8±535.1 pg/ml。黄体期相应的类固醇水平分别为：259.7±120.2 vs 382.7±188.7 pg/ml，7.0±4.8 vs 9.9±6.1 ng/ml，819.4±355.7 vs 1703.5±1058.1 pg/ml。使用Wilcoxon秩和检验发现，除黄体期的P外，术中激素水平均显著升高（p < 0.05）。结果表明，全身麻醉下的腹腔镜检查可能通过激活下丘脑 - 垂体 - 卵巢轴引起卵巢激素分泌增加。
