Settmacher U, Jahn S, Siegel P, von Baehr R, Hansen A
Clinic for Surgery, Medical School (Charité), Humboldt-University Berlin, FRG.
Mol Immunol. 1993 Jul;30(10):953-4. doi: 10.1016/0161-5890(93)90021-3.
The human hybridoma cell line CB-201 has been obtained from a fusion of fetal spleen lymphocytes (31st gestational week) with heteromyeloma cells. The IgM (lambda) secreted was found to bind to lipid A, whereas other endogenous and exogenous antigens were not recognized. The CB-201 antibody is encoded by the unmutated VH6 gene recombined with DN4 and JH3 elements and a V lambda subgroup 1 gene. Therefore, a VH gene, which was previously described to be over-represented in the fetal repertoire and to be expressed in autoantibody-producing B cells, may encode an anti-bacterial specificity.
人杂交瘤细胞系CB - 201是由胎儿脾淋巴细胞（妊娠第31周）与异骨髓瘤细胞融合获得的。发现其分泌的IgM（λ）与脂多糖结合，而未识别其他内源性和外源性抗原。CB - 201抗体由与DN4和JH3元件重排的未突变VH6基因以及Vλ亚群1基因编码。因此，一个先前被描述在胎儿抗体库中过度表达且在产生自身抗体的B细胞中表达的VH基因，可能编码一种抗细菌特异性。
