Davis J W, Arnold J, Wiegmann T
Department of Veterans Affairs Medical Center, Kansas City, Mo.
Nephron. 1993;64(3):359-64. doi: 10.1159/000187354.
Previous work has shown that cigarette-smoking affects platelets and endothelium in men and women without renal failure. The present study compared 10 male habitual smokers receiving maintenance hemodialysis for chronic renal failure with 11 healthy male habitual smokers before and after controlled cigarette-smoking after a 12-hour period of abstinence. Collagen-induced platelet aggregation was not significantly different in the two groups of men before smoking. The platelet aggregate ratio was lower and the plasma concentration of platelet factor 4 was higher in the dialysis patients than in the healthy men (p < 0.05). Mean or median values before and after cigarette smoking by the dialysis patients were 42 and 62 chart units for collagen-induced platelet aggregation, 0.88 and 0.77 for the platelet aggregate ratio, 6.2 and 8.5 ng/ml for the plasma concentration of platelet factor 4, 0.8 and 1.7 per counting chamber for the endothelial cell count and 4 and 37 ng/ml for the plasma nicotine concentration (each p < 0.01). None of the changes which occurred in the dialysis patients was statistically significantly different from those in the healthy men. We conclude that cigarette-smoking has similar effects on platelets and endothelium in patients receiving maintenance hemodialysis and in healthy controls.
先前的研究表明，吸烟会影响未患肾衰竭的男性和女性的血小板及内皮细胞。本研究比较了10名因慢性肾衰竭接受维持性血液透析的男性习惯性吸烟者与11名健康男性习惯性吸烟者在禁欲12小时后进行控制性吸烟前后的情况。两组男性在吸烟前，胶原诱导的血小板聚集无显著差异。透析患者的血小板聚集率较低，血小板因子4的血浆浓度高于健康男性（p < 0.05）。透析患者吸烟前后，胶原诱导的血小板聚集的均值或中位数分别为42和62图单位，血小板聚集率分别为0.88和0.77，血小板因子4的血浆浓度分别为6.2和8.5 ng/ml，内皮细胞计数分别为每计数室0.8和1.7，血浆尼古丁浓度分别为4和37 ng/ml（各p < 0.01）。透析患者发生的变化与健康男性相比，均无统计学显著差异。我们得出结论，吸烟对接受维持性血液透析的患者和健康对照者的血小板及内皮细胞有相似的影响。
