Saudek C D, Hemm R M, Peterson C M
Metabolism. 1977 Jan;26(1):43-52. doi: 10.1016/0026-0495(77)90126-3.
The question of whether iron overload causes glucose intolerance was studied in a group of 26 multiply transfused homozygous beta thalassemics. Of the 26, 13 (50%) had some abnormality in their oral glucose tolerance test, 5 fitting criteria for definite diabetes. Glucose intolerance correlated significantly with number of transfusions received and with age of the subjects, while a positive family history for diabetes was more common in the subjects with glucose intolerance. These data and a chart review of four deceased thalassemics with overt diabetes are consistent with the following conclusions: (1) glucose intolerance is common in multiply transfused thalassemics; (2) the incidence of abnormal glucose tolerance correlates with the number of transfusions received and the age of the subject; (3) a family history of diabetes may predisose multiply transfused thalassemics to glucose intolerance.
在一组26名多次输血的纯合子β地中海贫血患者中，研究了铁过载是否会导致葡萄糖耐受不良的问题。在这26名患者中，13名（50%）口服葡萄糖耐量试验存在一些异常，5名符合明确糖尿病的标准。葡萄糖耐受不良与输血次数和患者年龄显著相关，而糖尿病家族史在葡萄糖耐受不良的患者中更为常见。这些数据以及对4名已故显性糖尿病地中海贫血患者的图表回顾与以下结论一致：（1）葡萄糖耐受不良在多次输血的地中海贫血患者中很常见；（2）葡萄糖耐量异常的发生率与输血次数和患者年龄相关；（3）糖尿病家族史可能使多次输血的地中海贫血患者易患葡萄糖耐受不良。
