García Frade L J, García Avello A
Servicio de Hematología, Hospital Ramón y Cajal, Madrid.
Rev Clin Esp. 1993 Jun;193(2):88-92.
Thrombolytic therapy yields a 80% repermeabilitation in the acute myocardium infarct if applied soon. In other thrombotic sites such as deep venous thrombosis, pulmonary thromboembolism and peripheral arterial thrombosis, with no large cooperative randomized clinical trials, its usefulness is clear, tough selectively. The high rethrombosis frequency is the major drawback of this therapy. The concomitant use of an anti-thrombotic and/or anti-aggregant agent, even tough the possible higher risks of hemorrhages, seems a key element to improve the results obtained with thrombolysis.
溶栓治疗若尽早应用于急性心肌梗死，可使80%的心肌实现再灌注。在其他血栓形成部位，如深静脉血栓形成、肺血栓栓塞和外周动脉血栓形成，由于缺乏大型合作随机临床试验，其有效性虽有，但具有选择性。高再血栓形成频率是该治疗的主要缺点。同时使用抗血栓和/或抗聚集剂，尽管可能存在更高的出血风险，但似乎是改善溶栓治疗效果的关键因素。
