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The metabolic disposition of R-(+)-pulegone (I) was examined in rats following four daily oral doses (250 mg/kg). 2. Six metabolites, namely pulegol (II), 2-hydroxy-2-(1-hydroxy-1-methylethyl)-5-methylcyclohexanone (III), 3,6-dimethyl-7a-hydroxy-5,6,7,7a-tetrahydro-2(4H)-benzofuranone (IV), menthofuran (V), 5-methyl-2-(1-methyl-1-carboxyethylidene)cyclohexanone (VI), and 5-methyl-5-hydroxy-2-(1-hydroxy-1-carboxyethyl)cyclohexanone (VII) have previously been isolated from rat urine, and identified (Moorthy et al. (1989a). Eight new metabolites have now been isolated from rat urine, namely, 5-hydroxy-pulegone (VIII), piperitone (IX), piperitenone (X), 7-hydroxy-piperitone (XI), 8-hydroxy piperitone (XII), p-cresol (XIII), geranic acid (XIV) and neronic acid (XV). These were identified by n.m.r., i.r. and mass spectrometry. 3. Based on these results, metabolic pathways for the biotransformation of R-(+)-pulegone in rat have been proposed.

在大鼠中，每天口服四次剂量为250毫克/千克的R-(+)-胡薄荷酮（I）后，对其代谢情况进行了研究。2. 六种代谢产物，即胡薄荷醇（II）、2-羟基-2-(1-羟基-1-甲基乙基)-5-甲基环己酮（III）、3,6-二甲基-7a-羟基-5,6,7,7a-四氢-2(4H)-苯并呋喃酮（IV）、薄荷呋喃（V）、5-甲基-2-(1-甲基-1-羧基亚乙基)环己酮（VI）和5-甲基-5-羟基-2-(1-羟基-1-羧基乙基)环己酮（VII），此前已从大鼠尿液中分离并鉴定出来（穆尔蒂等人，(1989a)）。现在又从大鼠尿液中分离出八种新的代谢产物，即5-羟基-胡薄荷酮（VIII）、哌啶酮（IX）、哌啶烯酮（X）、7-羟基-哌啶酮（XI）、8-羟基哌啶酮（XII）、对甲酚（XIII）、香叶酸（XIV）和橙花酸（XV）。通过核磁共振、红外光谱和质谱对它们进行了鉴定。3. 根据这些结果，提出了大鼠体内R-(+)-胡薄荷酮生物转化的代谢途径。

The metabolic disposition of R-(+)-pulegone (I) was examined in rats following four daily oral doses (250 mg/kg). 2. Six metabolites, namely pulegol (II), 2-hydroxy-2-(1-hydroxy-1-methylethyl)-5-methylcyclohexanone (III), 3,6-dimethyl-7a-hydroxy-5,6,7,7a-tetrahydro-2(4H)-benzofuranone (IV), menthofuran (V), 5-methyl-2-(1-methyl-1-carboxyethylidene)cyclohexanone (VI), and 5-methyl-5-hydroxy-2-(1-hydroxy-1-carboxyethyl)cyclohexanone (VII) have previously been isolated from rat urine, and identified (Moorthy et al. (1989a). Eight new metabolites have now been isolated from rat urine, namely, 5-hydroxy-pulegone (VIII), piperitone (IX), piperitenone (X), 7-hydroxy-piperitone (XI), 8-hydroxy piperitone (XII), p-cresol (XIII), geranic acid (XIV) and neronic acid (XV). These were identified by n.m.r., i.r. and mass spectrometry. 3. Based on these results, metabolic pathways for the biotransformation of R-(+)-pulegone in rat have been proposed.

在大鼠中，每天口服四次剂量为250毫克/千克的R-(+)-胡薄荷酮（I）后，对其代谢情况进行了研究。2. 六种代谢产物，即胡薄荷醇（II）、2-羟基-2-(1-羟基-1-甲基乙基)-5-甲基环己酮（III）、3,6-二甲基-7a-羟基-5,6,7,7a-四氢-2(4H)-苯并呋喃酮（IV）、薄荷呋喃（V）、5-甲基-2-(1-甲基-1-羧基亚乙基)环己酮（VI）和5-甲基-5-羟基-2-(1-羟基-1-羧基乙基)环己酮（VII），此前已从大鼠尿液中分离并鉴定出来（穆尔蒂等人，(1989a)）。现在又从大鼠尿液中分离出八种新的代谢产物，即5-羟基-胡薄荷酮（VIII）、哌啶酮（IX）、哌啶烯酮（X）、7-羟基-哌啶酮（XI）、8-羟基哌啶酮（XII）、对甲酚（XIII）、香叶酸（XIV）和橙花酸（XV）。通过核磁共振、红外光谱和质谱对它们进行了鉴定。3. 根据这些结果，提出了大鼠体内R-(+)-胡薄荷酮生物转化的代谢途径。

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