Bichel T, Joris J, Jacquet N, Lamy M
Département of Anesthesiology, University Hospital of Liège, Belgium.
Acta Anaesthesiol Belg. 1993;44(1):25-9.
The authors report the case of a female patient with South-African genetic porphyria who had to undergo hepatic tumorectomy under general anesthesia. The choice for propofol as the induction and maintenance agent using a balanced anesthetic technique led to a significant rise in urinary excretion of porphyrins without associated clinical manifestations. A short review of the literature on physiopathology of porphyrias and medicinal agents, susceptible to induce acute porphyric crisis follows. The authors conclude that the innocuity of propofol as induction and maintaining agent in the porphyric patient cannot be yet established without further studies.
作者报告了一例患有南非遗传性卟啉病的女性患者，该患者必须在全身麻醉下接受肝脏肿瘤切除术。选择丙泊酚作为诱导和维持药物并采用平衡麻醉技术，导致卟啉尿排泄显著增加，但无相关临床表现。随后对卟啉病的生理病理学及可能诱发急性卟啉病危机的药物进行了简短的文献综述。作者得出结论，在没有进一步研究的情况下，丙泊酚作为卟啉病患者诱导和维持药物的安全性尚未确立。
