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系统性红斑狼疮患者血清中凝血蛋白C抗体的存在与抗原性或功能性蛋白C缺乏无关。

Presence of serum antibodies to coagulation protein C in patients with systemic lupus erythematosus is not associated with antigenic or functional protein C deficiencies.

作者信息

Ruiz-Arguelles A, Vazquez-Prado J, Deleze M, Perez-Romano B, Drenkard C, Alarcon-Segovia D, Ruiz-Arguelles G J

机构信息

Laboratorios Clinicos de Puebla, Instituto Nacional de la Nutricion Salvador Zubiran, Mexico City, Mexico.

出版信息

Am J Hematol. 1993 Sep;44(1):58-9. doi: 10.1002/ajh.2830440112.

DOI:10.1002/ajh.2830440112
PMID:8342565
Abstract

Antibodies directed to immunopurified coagulation protein C (PC) were investigated in serum samples from 108 patients with systemic lupus erythematosus (SLE) and found in 12 of them. However, their presence was not associated with antigenic or functional deficiencies of PC, which were documented in 6 and 17 patients, respectively.

摘要

在108例系统性红斑狼疮（SLE）患者的血清样本中研究了针对免疫纯化凝血蛋白C（PC）的抗体，结果在其中12例患者中发现了此类抗体。然而，它们的存在与PC的抗原性或功能缺陷并无关联，PC的抗原性和功能缺陷分别在6例和17例患者中得到证实。

相似文献

1
Presence of serum antibodies to coagulation protein C in patients with systemic lupus erythematosus is not associated with antigenic or functional protein C deficiencies.系统性红斑狼疮患者血清中凝血蛋白C抗体的存在与抗原性或功能性蛋白C缺乏无关。
Am J Hematol. 1993 Sep;44(1):58-9. doi: 10.1002/ajh.2830440112.
2
Studies of natural anticoagulant proteins and anticardiolipin antibodies in patients with the lupus anticoagulant.狼疮抗凝物患者体内天然抗凝蛋白及抗心磷脂抗体的研究。
Br J Haematol. 1990 Nov;76(3):380-6. doi: 10.1111/j.1365-2141.1990.tb06372.x.
3
[Lupus anticoagulant as a risk factor of thrombosis].狼疮抗凝物作为血栓形成的一个危险因素
Pol Tyg Lek. 1992;47(5-6):154-5.
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Antiphospholipid antibodies in systemic lupus erythematosus.
Tokai J Exp Clin Med. 1990 May;15(2-3):241-4.
5
Association between the prevalence of antibodies to beta(2)-glycoprotein I, prothrombin, protein C, protein S, and annexin V in patients with systemic lupus erythematosus and thrombotic and thrombocytopenic complications.系统性红斑狼疮患者中β2糖蛋白I、凝血酶原、蛋白C、蛋白S和膜联蛋白V抗体的流行率与血栓形成及血小板减少并发症之间的关联
Clin Chem. 2001 Jun;47(6):1008-15.
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Effects of coagulation temperature on measurements of complement function in serum samples from patients with systemic lupus erythematosus.凝血温度对系统性红斑狼疮患者血清样本中补体功能测定的影响。
Ann Rheum Dis. 1992 Jul;51(7):892-7. doi: 10.1136/ard.51.7.892.
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[Antihistones antibodies in systemic lupus erythematosus, comparison of three assays: Elisa, dot blot and immunoblot].[系统性红斑狼疮中的抗组蛋白抗体：三种检测方法（酶联免疫吸附测定、斑点印迹法和免疫印迹法）的比较]
Pathol Biol (Paris). 2006 Apr;54(3):148-54. doi: 10.1016/j.patbio.2005.07.011. Epub 2005 Sep 15.
8
Inflammation and thrombosis: the impact of inflammation on the protein C anticoagulant pathway.
Haematologica. 1995 Mar-Apr;80(2 Suppl):49-56.
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Natural anticoagulants in systemic lupus erythematosus. Deficiency of protein S bound to C4bp associates with recent history of venous thromboses, antiphospholipid antibodies, and the antiphospholipid syndrome.
J Rheumatol. 1991 Apr;18(4):552-8.
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Abnormalities in the protein C anticoagulant pathway detected by a novel assay using human thrombomodulin.采用新型人血栓调节蛋白检测法检测蛋白C抗凝途径异常。
Lupus. 1997;6(7):590-6. doi: 10.1177/096120339700600706.

引用本文的文献

1
Binding of anticardiolipin antibodies to protein C via beta2-glycoprotein I (beta2-GPI): a possible mechanism in the inhibitory effect of antiphospholipid antibodies on the protein C system.抗心磷脂抗体通过β2-糖蛋白I（β2-GPI）与蛋白C结合：抗磷脂抗体对蛋白C系统产生抑制作用的一种可能机制。
Clin Exp Immunol. 1998 May;112(2):325-33. doi: 10.1046/j.1365-2249.1998.00582.x.
2
The antiphospholipid-protein syndrome.抗磷脂蛋白综合征
J Clin Immunol. 1995 Nov;15(6 Suppl):86S-100S. doi: 10.1007/BF01540898.
3
Antigenic specificities of "antiphospholipid" autoantibodies.
“抗磷脂”自身抗体的抗原特异性
Springer Semin Immunopathol. 1994;16(2-3):211-22. doi: 10.1007/BF00197518.