Salemi C, Morgan J W, Kelleghan S I, Hiebert-Crape B
Department of Infection Control, Kaiser Permanente Medical Center, Fontana, CA 92335.
Am J Infect Control. 1993 Jun;21(3):117-26. doi: 10.1016/0196-6553(93)90002-l.
A subjective severity of illness classification was evaluated in a study of nosocomial pneumonia. This is a 5-category system based on the determination of the control of underlying illness and the risk of death during current hospital admission.
A case-control study was performed with 128 cases of nosocomial pneumonia and 252 control patients. An additional 60 case and 90 control patients were used to compare this classification with APACHE II scoring in intensive care unit patients.
In univariate analysis, the severity illness classification was significantly associated with nosocomial pneumonia risk (p < 0.01). APACHE II adequately predicted mortality rate but was not statistically significantly associated with nosocomial pneumonia risk among intensive care unit patients. In logistic regression analysis, the severity of illness classification, surgery, age, nasogastric tube placement, and histamine blockers each showed significant independent association with nosocomial pneumonia.
The role of the severity of illness classification for risk stratification in nosocomial pneumonia is valid. Its roles in the evaluation of surgical wound infection, nosocomial bacteremia, and quality of care remain to be determined in subsequent studies.
在一项医院获得性肺炎研究中对疾病严重程度的主观分类进行了评估。这是一个基于对基础疾病控制情况及本次住院期间死亡风险判定的五分类系统。
开展了一项病例对照研究,其中有128例医院获得性肺炎病例和252例对照患者。另外使用60例病例和90例对照患者,将该分类与重症监护病房患者的急性生理与慢性健康状况评分系统II(APACHE II)进行比较。
在单因素分析中,疾病严重程度分类与医院获得性肺炎风险显著相关(p < 0.01)。APACHE II能充分预测死亡率,但在重症监护病房患者中与医院获得性肺炎风险无统计学显著关联。在逻辑回归分析中,疾病严重程度分类、手术、年龄、鼻胃管置入及组胺阻滞剂各自均显示与医院获得性肺炎有显著独立关联。
疾病严重程度分类在医院获得性肺炎风险分层中的作用是有效的。其在手术伤口感染、医院获得性菌血症及医疗质量评估中的作用有待后续研究确定。