Somerville P, Wray R C
University of Rochester, Division of Plastic Surgery, NY 14642.
Ann Plast Surg. 1993 May;30(5):449-50; discussion 450-1. doi: 10.1097/00000637-199305000-00010.
We report a unique patient with true asymmetrical hypersensitivity to bovine collagen. Hypersensitivity is the development of an inflammatory response at a treatment site after a negative skin test. She developed an inflammatory response in only one of two simultaneously injected sites. About 1.5% of patients with a negative skin test have a hypersensitivity reaction consisting of firmness, erythema, and swelling. The signs and symptoms generally resolve spontaneously in a few months.