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手性血小板活化因子激动剂：合成、其立体电子性质的理论分析及构效关系

Chiral PAF agonists: synthesis, theoretical analysis of their stereoelectronic properties and structure activity relationships.

作者信息

Villa L, Pallavicini M, Villa A M, Valoti E, Ferri V, Maderna P

机构信息

Istituto Di Chimica Farmaceutica e Tossicologica, Università di Milano.

出版信息

Farmaco. 1993 May;48(5):573-613.

PMID:8343209
Abstract

A series of chiral PAF agonists were synthesized. Modifications at the PAF structure were undertaken as far as the C2 substituents and the onium head groups are concerned. In parallel, molecular modelling studies including a MOPAC geometry optimization and the analysis of the electrostatic potential were performed on the newly synthesized and on already known PAF agonists, in order to gain a better insight into the stereoelectronic features required for interaction with the PAF receptor.

摘要

合成了一系列手性血小板活化因子（PAF）激动剂。就C2取代基和鎓头基团而言，对PAF结构进行了修饰。同时，对新合成的和已知的PAF激动剂进行了包括MOPAC几何优化和静电势分析在内的分子建模研究，以便更好地了解与PAF受体相互作用所需的立体电子特征。

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1
Chiral PAF agonists: synthesis, theoretical analysis of their stereoelectronic properties and structure activity relationships.手性血小板活化因子激动剂：合成、其立体电子性质的理论分析及构效关系
Farmaco. 1993 May;48(5):573-613.
2
Agonistic activity and charge driven interaction potentiality of PAF derivatives.血小板激活因子（PAF）衍生物的激动活性和电荷驱动相互作用潜力。
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