Britten R A, Warenius H M
Department of Medicine, University of Liverpool, U.K.
Eur J Cancer. 1993;29A(9):1315-20. doi: 10.1016/0959-8049(93)90081-p.
The intrinsic sensitivity to 4 MeV photons, and 62.5 MeV (p-->Be+) neutrons has been examined in a panel of 11 cultured human cell lines exhibiting a wide spectrum of inherent cisplatinum sensitivity. Irrespective of whether cellular sensitivities to these therapeutic agents were compared at the 10% survival level, relative to the initial portion of the cell survival curves, or to their relative rank order of response, there were no significant correlations between inherent cisplatinum sensitivity and sensitivity to either 4 MeV photon, or 62.5 MeV neutron irradiation. This data raises the possibility that the previously reported decreased radiosensitivity of human tumour cell lines with acquired cisplatinum resistance may be due to the induction of cellular processes which confer resistance to both cisplatinum and ionising radiation, rather than the selection of innately cisplatinum-resistant cells, which are collaterally radioresistant.
在一组11种培养的人类细胞系中检测了对4兆电子伏光子和62.5兆电子伏（p→Be+）中子的内在敏感性，这些细胞系表现出广泛的固有顺铂敏感性。无论将细胞对这些治疗剂的敏感性在10%存活水平下进行比较，相对于细胞存活曲线的初始部分，还是比较它们的相对反应等级顺序，固有顺铂敏感性与对4兆电子伏光子或62.5兆电子伏中子照射的敏感性之间均无显著相关性。该数据增加了一种可能性，即先前报道的获得性顺铂耐药的人类肿瘤细胞系放射敏感性降低，可能是由于诱导了赋予对顺铂和电离辐射均耐药的细胞过程，而不是选择了天生对顺铂耐药且对辐射有抗性的细胞。
