Hong S J, Woo H C, Lee S Y, Ahn J H, Park C K, Chai J Y, Lee S H
Department of Parasitology, College of Medicine, Gyeong-Sang National University, Chinju, Korea.
Korean J Parasitol. 1993 Jun;31(2):109-16. doi: 10.3347/kjp.1993.31.2.109.
Worm recovery rates and pathologic changes in small intestine of albino rats were observed after concurrent and challenge infections with metacercariae (MC) of Fibricola seoulensis and Metagonimus yokogawai, and compared with those of single infection groups. Albino rats in concurrent infection group were killed 20 days after feeding with 1,000 MC of each fluke. Rats in challenge infection group were fed with 1,000 MC of F. seoulensis and challenged by 1,000 MC of M. yokogawai 10 days after primary infection, then killed 10 days thereafter. In concurrent infection group, mean number of F. seoulensis and M. yokogawai recovered, 250 and 118 respectively, were similar to those of single infection groups. However, more flukes were collected from the duodenum and less flukes were from the ileum than from single infection group. In challenge infection group, the recovery rate of F. seoulensis was similar to that of single infection group and the distribution of the flukes was similar to that of concurrent infection group. Mean number of M. yokogawai, 69, was significantly lower than that of single infection group. Its distribution, however, extended to the duodenum and most of the flukes were recovered from the jejunum. In concurrent infection group, villi of the duodenum were more markedly thickened, fused and shortened than those in F. seoulensis single infection group. The crypt epithelium appeared to be hyperplastic and inflammatory cell infiltration into the villous stroma was mild. Villous atrophy in the jejunum and ileum was milder than in M. yokogawai single infection group. In challenge infection group, the findings were similar to those of concurrent infection group.(ABSTRACT TRUNCATED AT 250 WORDS)
观察了白化大鼠同时感染和感染后再感染汉城棘口吸虫和横川后殖吸虫囊蚴后的虫体回收率及小肠病理变化，并与单感染组进行比较。同时感染组的白化大鼠在分别喂食1000个每种吸虫的囊蚴后20天处死。感染后再感染组的大鼠先喂食1000个汉城棘口吸虫囊蚴，在初次感染10天后再用1000个横川后殖吸虫囊蚴进行攻击感染，然后在10天后处死。在同时感染组中，回收的汉城棘口吸虫和横川后殖吸虫的平均数量分别为250条和118条，与单感染组相似。然而，与单感染组相比，从十二指肠收集到的吸虫更多，从回肠收集到的吸虫更少。在感染后再感染组中，汉城棘口吸虫的回收率与单感染组相似，吸虫的分布与同时感染组相似。横川后殖吸虫的平均数量为69条，显著低于单感染组。然而，其分布扩展到十二指肠，大多数吸虫是从空肠回收的。在同时感染组中，十二指肠绒毛比汉城棘口吸虫单感染组更明显地增厚、融合和缩短。隐窝上皮似乎增生，绒毛基质中的炎性细胞浸润较轻。空肠和回肠的绒毛萎缩比横川后殖吸虫单感染组轻。在感染后再感染组中，结果与同时感染组相似。（摘要截短至250字）
