Salathe E P, Chen C
Institute for Biomedical Engineering and Mathematical Biology, Lehigh University, Bethlehem, Pennsylvania 18015.
Math Biosci. 1993 Jul;116(1):1-20. doi: 10.1016/0025-5564(93)90059-j.
Myoglobin retards the development of anoxia in a poorly perfused region of skeletal muscle by facilitating diffusion into this region from adjacent normally perfused regions and by releasing bound oxygen directly into the tissue. We examine these phenomena by analyzing a mathematical model of time-dependent myoglobin-facilitated oxygen transport. The governing equations are solved using similarity transformations and multiple-scale techniques. We find that when perfusion of a region is suddenly decreased, oxygen depletion is significantly retarded by direct release of myoglobin-bound oxygen into the tissue and that myoglobin-facilitated diffusion of oxygen from adjacent regions becomes significant at very low oxygen concentration.
肌红蛋白通过促进氧气从相邻正常灌注区域扩散到骨骼肌灌注不良区域，并通过将结合的氧气直接释放到组织中，来延缓该区域缺氧的发展。我们通过分析一个随时间变化的肌红蛋白促进氧气运输的数学模型来研究这些现象。使用相似变换和多尺度技术求解控制方程。我们发现，当一个区域的灌注突然减少时，肌红蛋白结合的氧气直接释放到组织中可显著延缓氧气消耗，并且在极低的氧气浓度下，肌红蛋白促进氧气从相邻区域的扩散变得显著。
