Rana A, Chisholm G D, Christodoulou S, McIntyre M A, Elton R A
University Department of Surgery/Urology, Western General Hospital, Edinburgh.
Br J Urol. 1993 Jun;71(6):721-7. doi: 10.1111/j.1464-410x.1993.tb16073.x.
An analysis was made of a prospective database of 614 men with newly diagnosed carcinoma of the prostate who presented between January 1978 and December 1990; 3-monthly updates were available on their clinical, haematological and biochemical parameters and 6-monthly updates on chest X-rays, bone scans and skeletal X-rays. It was found that 107 men (mean age 73.5 years) had early disease at presentation. Their management was based on regular surveillance and the treatment deferred until disease progression or development of symptoms. The audit of outcome measured various clinical events. Four patients (3.7%) developed local failure, 11 (10.3%) developed bone metastases, 3 (2.8%) died of cancer with a median survival of 6.3 years, and 34 (31.8%) died of intercurrent disease with a median survival of 2.6 years. The observed survival for 12 years of the whole group was similar to the expected survival for an age-matched population in Scotland. The standardised mortality ratio was 81 (95% confidence limits 57-112).
对一个前瞻性数据库进行了分析，该数据库包含1978年1月至1990年12月期间新诊断为前列腺癌的614名男性；每3个月更新一次他们的临床、血液学和生化参数，每6个月更新一次胸部X光、骨扫描和骨骼X光检查结果。结果发现，107名男性（平均年龄73.5岁）在就诊时患有早期疾病。他们的治疗基于定期监测，治疗推迟到疾病进展或出现症状时进行。对结果的审核衡量了各种临床事件。4名患者（3.7%）出现局部失败，11名（10.3%）出现骨转移，3名（2.8%）死于癌症，中位生存期为6.3年，34名（31.8%）死于并发疾病，中位生存期为2.6年。整个组12年的观察生存率与苏格兰年龄匹配人群的预期生存率相似。标准化死亡率为81（95%置信区间57 - 112）。
