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cDNA cloning of the sodium-influx-stimulating peptide in the mollusc, Lymnaea stagnalis.

作者信息

Smit A B, Thijsen S F, Geraerts W P

机构信息

Graduate School Neurosciences Amsterdam, Faculty of Biology, Department of Zoology, Vrije Universiteit, The Netherlands.

出版信息

Eur J Biochem. 1993 Jul 15;215(2):397-400. doi: 10.1111/j.1432-1033.1993.tb18046.x.

DOI:10.1111/j.1432-1033.1993.tb18046.x
PMID:8344306
Abstract

We isolated and characterized a cDNA clone, encoding the prohormone of the sodium-influx-stimulating (SIS) peptide of the freshwater snail Lymnaea stagnalis. The prohormone is cleaved to generate a signal peptide of 23 amino acids and a SIS peptide of 77 amino acids. The SIS peptide as encoded by the cDNA represents a novel and complex neuropeptide, which controls the activity of sodium pumps in the integument, pericardium, ureter and nephridial gland. In situ hybridization showed that the SIS-peptide gene is expressed by the neuroendocrine, so-called Yellow Cells of the central nervous system.

摘要

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