Tarraza H M, Muntz H G, De Cain M, Jones M A
Department of Obstetrics and Gynecology, Maine Medical Center, Portland.
Eur J Gynaecol Oncol. 1993;14(4):274-8.
Cervical metastases from ovarian malignancies are a rare event. In order to better define the incidence and pathogenesis of this phenomenon we retrospectively reviewed the charts and pathologic material from 171 Stage III ovarian malignancies. Nine patients (5.3%) were identified with cervical metastases and three patterns of spread to the cervix were recognized: 1) lymphatic permeation only; 2) para-cervical soft tissue extension and 3) direct stromal myometrial invasion. All of the patients with cervical metastases had high grade (Broder's grade III or IV) tumors and extensive abdominal disease at presentation. Although four patients had a positive or suspicious pap smear, none of these had cervical involvement. We conclude that ovarian metastases to the cervix are a rare event, occurring late in the course of the disease and arise from a variety of modes of spread.
卵巢恶性肿瘤的宫颈转移是一种罕见情况。为了更好地界定这一现象的发生率和发病机制，我们回顾性分析了171例III期卵巢恶性肿瘤的病历及病理资料。9例患者（5.3%）被确诊有宫颈转移，且发现了三种宫颈转移模式：1）仅淋巴管浸润；2）宫颈旁软组织浸润；3）直接浸润子宫肌层。所有有宫颈转移的患者均为高分级（Broder分级III级或IV级）肿瘤，初诊时腹部已有广泛病变。虽然4例患者巴氏涂片呈阳性或可疑，但均无宫颈受累。我们得出结论，卵巢肿瘤转移至宫颈是罕见情况，发生于疾病晚期，且有多种转移途径。
