Biswas S, Biswas S K, Bhattacharyya A K
Department of Biochemistry, Calcutta University College of Science.
Indian J Med Res. 1993 Apr;98:96-101.
Correlation of tri-ortho-cresyl phosphate (TOCP) toxicity with clinical symptoms and inhibition patterns of neurotoxic esterase (NTE) in different regions of the central nervous system was studied in hens. The total content of NTE in spinal cord and peripheral nerves was relatively much lower than that of the brain, about 29 and 4.8 per cent respectively. Brain and spinal cord NTE was inhibited to 75 and 67 per cent respectively on day 1 post-TOCP treatment, and 91 and 84 per cent respectively on day 2, while the activity of the enzyme in peripheral nerve was inhibited to 92 per cent on day 1. However, the clinical manifestations of paralysis appeared after 7-8 days of TOCP treatment. It can be concluded that the presence of NTE in very low quantities in the peripheral nerves and its almost complete inhibition as compared to that of brain and spinal cord, could be of great significance in the development of neurotoxicity.
在母鸡身上研究了磷酸三邻甲苯酯（TOCP）毒性与中枢神经系统不同区域神经毒性酯酶（NTE）的临床症状及抑制模式之间的相关性。脊髓和外周神经中NTE的总含量相对比大脑中的低得多，分别约为29%和4.8%。TOCP处理后第1天，大脑和脊髓中的NTE分别被抑制到75%和67%，第2天分别被抑制到91%和84%，而外周神经中该酶的活性在第1天被抑制到92%。然而，TOCP处理7 - 8天后才出现麻痹的临床表现。可以得出结论，外周神经中NTE含量极低，且与大脑和脊髓相比其几乎完全被抑制，这可能在神经毒性的发展中具有重要意义。
