Schwartz A M, Silverberg S G, Fu Y S, Nozawa S, Huang S, Tsukasaki K, Williams K R
Department of Pathology, George Washington University Medical Center, Washington, D.C.
Int J Gynecol Pathol. 1993 Jul;12(3):253-8. doi: 10.1097/00004347-199307000-00009.
Forty patients, originally diagnosed as endometrial hyperplasia, were reviewed histopathologically and evaluated for immunohistochemical staining with antibodies directed against TAG-72 and MSN-1 antigens. All patients had follow-up endometrial biospies or hysterectomies from 1 to 13 years later. The extent of regression to normal of nonhyperplastic endometrium, persistence as any type of endometrial hyperplasia, or progression to endometrial adenocarcinoma was correlated with the histologic hyperplastic subtype and immunohistochemical staining. As expected, cases of complex or atypical hyperplasia more often progressed to carcinoma than cases of simple or no hyperplasia. Interestingly, MSN-1 positivity was more prevalent in cases of higher grades than lower grades of hyperplasia and was associated with the tendency to show persistent hyperplasia or progression to carcinoma. B72.3 positivity was uncommon in the hyperplastic endometrium and was not correlated with clinical regression or progression. Although the tendency for progression of endometrial hyperplasia to endometrial carcinoma is best judged histologically, MSN-1 may add prognostic information in subgroups of hyperplasia.
对最初诊断为子宫内膜增生的40例患者进行了组织病理学复查，并用抗TAG - 72和MSN - 1抗原的抗体进行免疫组化染色评估。所有患者在1至13年后均进行了子宫内膜活检或子宫切除术随访。非增生性子宫内膜恢复正常的程度、作为任何类型子宫内膜增生持续存在的情况或进展为子宫内膜腺癌的情况与组织学增生亚型和免疫组化染色相关。正如预期的那样，复杂或非典型增生病例比单纯或无增生病例更常进展为癌。有趣的是，MSN - 1阳性在增生程度较高的病例中比在较低程度的病例中更普遍，并且与显示持续性增生或进展为癌的倾向相关。B72.3阳性在增生性子宫内膜中不常见，且与临床消退或进展无关。虽然子宫内膜增生进展为子宫内膜癌的倾向最好通过组织学判断，但MSN - 1可能会为增生亚组增加预后信息。
