局部麻醉药物会降低猪睫状动脉的内皮依赖性舒张功能。
Local anesthetic drugs reduce endothelium-dependent relaxations of porcine ciliary arteries.
作者信息
Meyer P, Flammer J, Lüscher T F
机构信息
Department of Research, University Hospital, Basel, Switzerland.
出版信息
Invest Ophthalmol Vis Sci. 1993 Aug;34(9):2730-6.
PURPOSE
During retrobulbar anesthesia ocular hemodynamics are altered. The purpose of this study is to investigate the effects of local anesthetics in isolated porcine ciliary arteries (diameter between 200 and 400 microns).
METHODS
Isolated porcine ciliary arteries were suspended in myograph systems filled with modified Krebs-Ringer solution for isometric tension recording.
RESULTS
In quiescent or serotonin-precontracted arteries, lidocaine, bupivacaine, or mepivacaine (10(-9)-10(-5)M) evoked no change in vascular tone. However, all local anesthetics (10(-5)M) and bupivacaine (10(-5)-10(-6)M) reduced endothelium-dependent relaxations to bradykinin (10(-9)-10(-6)M), whereas the endothelium-independent relaxations to the nitric oxide-donor 3-morpholino-sydnonimine (SIN-1; 10(-9)-10(-5)M) were unaffected by local anesthetics. The addition of L-arginine (10(-4)M) markedly reduced the inhibitory effects of bupivacaine on endothelial vasodilatation function.
CONCLUSION
These findings demonstrate that in porcine ciliary arteries, local anesthetics impair endothelial formation of nitric oxide from L-arginine after stimulation with bradykinin, which may contribute importantly to the reduction in blood flow to the eye during retrobulbar anesthesia.
目的
球后麻醉期间眼血流动力学发生改变。本研究旨在探讨局部麻醉药对分离的猪睫状动脉（直径200至400微米）的影响。
方法
将分离的猪睫状动脉悬挂于充满改良克雷布斯-林格溶液的肌动描记系统中，以记录等长张力。
结果
在静息或血清素预收缩的动脉中，利多卡因、布比卡因或甲哌卡因（10⁻⁹ - 10⁻⁵M）未引起血管张力变化。然而，所有局部麻醉药（10⁻⁵M）和布比卡因（10⁻⁵ - 10⁻⁶M）均降低了对缓激肽（10⁻⁹ - 10⁻⁶M）的内皮依赖性舒张，而对一氧化氮供体3-吗啉代西多胺（SIN-1；10⁻⁹ - 10⁻⁵M）的非内皮依赖性舒张不受局部麻醉药影响。添加L-精氨酸（10⁻⁴M）可显著降低布比卡因对内皮血管舒张功能的抑制作用。
结论
这些发现表明，在猪睫状动脉中，局部麻醉药会损害缓激肽刺激后L-精氨酸生成一氧化氮的内皮过程，这可能对球后麻醉期间眼部血流减少起重要作用。
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