Croom W J, Bird A R, Black B L, McBride B W
Department of Animal Science and Department of Zoology, North Carolina State University, Raleigh 27695.
J Dairy Sci. 1993 Jul;76(7):2112-24. doi: 10.3168/jds.S0022-0302(93)77546-3.
Discussed herein are the constraints of nutrient delivery from the gastrointestinal tract that are placed on postabsorptive synthetic processes in highly selected strains of domestic livestock or livestock treated with growth promotants exogenously or via transgenic manipulation. Emphasis is placed on the discussion of recent advances in the knowledge of the regulation and manipulation of digestion and the absorption by the intestinal epithelium. Slaframine, a muscarinic exocrine secretagogue with a high affinity for the gastrointestinal tract, and epidermal growth factor may have practical potential for the manipulation of digestion and absorption, respectively. Special consideration is given to energetic considerations that must accompany any manipulation of gastrointestinal function. Down-regulation and up-regulation of mechanisms must be equally considered as this area is explored further.
本文讨论了在家畜的高度选育品种或经外源生长促进剂处理或通过转基因操作的家畜中，胃肠道营养物质输送对吸收后合成过程的限制。重点讨论了消化调节和肠道上皮吸收方面知识的最新进展。斯拉菌素是一种对胃肠道具有高亲和力的毒蕈碱外分泌促分泌剂，表皮生长因子可能分别在消化和吸收的调控方面具有实际应用潜力。特别考虑了任何胃肠道功能调控所必须伴随的能量因素。随着该领域的进一步探索，机制的下调和上调必须同样加以考虑。
