Lepola U M, Rimón R H, Riekkinen P J
Vaajasalo Hospital, Kuopio, Finland.
Int Clin Psychopharmacol. 1993 Summer;8(2):115-8. doi: 10.1097/00004850-199300820-00006.
Fifty-five patients with moderate to sever panic disorder were treated for 9 weeks with alprazolam or imipramine and were then, except for one patient who had committed suicide, re-examined after on average 3 years of treatment. At follow-up most patients (74%) did not suffer from panic attacks at all. In the beginning of the study 87% exhibited phobic avoidance behaviour but after 3 years 68% no longer revealed phobic behaviour. At follow-up 28% of the patients were no longer having psychotropic drug treatment and 20% were completely free of overt psychopathology. No tolerance phenomena were associated with the long-term medication applied in the study.
55名中重度惊恐障碍患者接受了9周的阿普唑仑或丙咪嗪治疗，除1名自杀患者外，平均经过3年治疗后进行了复查。随访时，大多数患者（74%）完全没有惊恐发作。研究开始时，87%的患者表现出恐惧回避行为，但3年后，68%的患者不再有恐惧行为。随访时，28%的患者不再接受精神药物治疗，20%的患者完全没有明显的精神病理学症状。该研究中应用的长期药物治疗未出现耐受性现象。
