Chiang C H, Lee A R, Lin C H
School of Pharmacy, National Defense Medical Center, Taipei, Taiwan, Republic of China.
J Ocul Pharmacol. 1993 Summer;9(2):109-15. doi: 10.1089/jop.1993.9.109.
A series of thiadiazole derivatives were topically applied in gels or suspensions to rabbits to determine their ocular hypotensive effect. As a result, the compounds with higher corneal permeabilities showed stronger effect in lowering IOP. In addition, gels also caused stronger effect than suspensions. Different concentrations of gel preparations produced diverse ocular hypotensive effects. A linear relationship between the integrated IOP response and logarithm concentration of inhibitor was found. It is proposed that the ocular hypotensive effect was attributed to the level of inhibitor in ciliary body.
将一系列噻二唑衍生物以凝胶或悬浮液的形式局部应用于兔子，以确定它们的降眼压效果。结果，角膜渗透率较高的化合物在降低眼压方面显示出更强的效果。此外，凝胶引起的效果也比悬浮液更强。不同浓度的凝胶制剂产生了不同的降眼压效果。发现眼压综合反应与抑制剂对数浓度之间存在线性关系。有人提出，降眼压效果归因于睫状体中抑制剂的水平。
