Umemori Y, Chiba H, Moriyama T, Takeda S, Hosokawa H, Nobuoka M, Makino M, Eto M, Akiyama K
Clinical Laboratories, Asahikawa Medical College Hospital.
Rinsho Byori. 1993 Mar;41(3):307-12.
A remarkable elevation of serum HDL cholesterol concentration (165mg/dl) was found in a 42-year-old Japanese male with chronic pancreatitis who had been cholestatic for several years. An abnormal slow alpha-migrating lipoprotein, larger in particle size and more enriched with cholesteryl ester and apo E than normal HDL, was found in the patient's plasma. Quantitative determination of apo E-rich HDL revealed a striking increase of this lipoprotein in plasma. After choledocho-jejunostomy, a prompt and remarkable decrease of plasma apo E-rich HDL was observed, indicating a direct contribution of cholestasis to the accumulation of apo E-rich HDL in plasma in this patient.
在一名患有慢性胰腺炎且胆汁淤积数年的42岁日本男性患者中，发现血清高密度脂蛋白胆固醇浓度显著升高（165mg/dl）。在患者血浆中发现一种异常缓慢的α迁移脂蛋白，其颗粒大小比正常高密度脂蛋白更大，胆固醇酯和载脂蛋白E含量更高。对富含载脂蛋白E的高密度脂蛋白进行定量测定发现，该脂蛋白在血浆中显著增加。胆总管空肠吻合术后，观察到血浆中富含载脂蛋白E的高密度脂蛋白迅速且显著下降，表明胆汁淤积对该患者血浆中富含载脂蛋白E的高密度脂蛋白的积聚有直接影响。
