Kubota S, Tamai H, Ishimoto-Goto J, Nozaki T, Kobayashi N, Matsubayashi S, Nakagawa T, Aoki T T
Department of Psycosomatic Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Metabolism. 1993 Aug;42(8):928-31. doi: 10.1016/0026-0495(93)90002-6.
Twenty-one hospitalized anorexia nervosa (AN) patients underwent a 50-g glucose challenge. All patients were then fed for 10 days and divided into two groups based on weight gain. Group AN-a (n = 10) gained little or no body weight over the 10-day period, whereas the second group, AN-b (n = 11), did gain weight during the same period. A third group of normal women (n = 10) served as control subjects (NC). Following ingestion of 50 g of glucose, group AN-a showed virtually the same nonprotein respiratory quotient (NPRQ) response as group NC. Group AN-b showed significant increases in basal and glucose-stimulated NPRQ and carbohydrate oxidation rate responses compared with group NC. Serum insulin responses in both AN groups were lower than those of group NC. These results indicate that insulin sensitivity in both liver and muscle may be increased in AN patients, and that refeeding tends to increase body weight rapidly in some patients due to this mechanism.
21名住院的神经性厌食症（AN）患者接受了50克葡萄糖耐量试验。然后所有患者接受为期10天的喂养，并根据体重增加情况分为两组。AN-a组（n = 10）在10天期间体重几乎没有增加或没有增加，而第二组AN-b组（n = 11）在同一时期体重增加。第三组正常女性（n = 10）作为对照受试者（NC）。摄入50克葡萄糖后，AN-a组显示出与NC组几乎相同的非蛋白呼吸商（NPRQ）反应。与NC组相比，AN-b组的基础和葡萄糖刺激的NPRQ以及碳水化合物氧化率反应显著增加。两个AN组的血清胰岛素反应均低于NC组。这些结果表明，AN患者肝脏和肌肉中的胰岛素敏感性可能增加，并且由于这种机制，重新喂养往往会使一些患者体重迅速增加。
