两名急性淋巴细胞白血病完全缓解患者发生侵袭性曲霉病。

Invasive aspergillosis in two patients with acute lymphoblastic leukaemia in complete remission.

作者信息

Turner M L, Russell L, Milne L J, Parker A C

机构信息

Department of Haematology, Royal Infirmary of Edinburgh, UK.

出版信息

Postgrad Med J. 1993 May;69(811):405-8. doi: 10.1136/pgmj.69.811.405.

DOI:10.1136/pgmj.69.811.405

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2399811/

Abstract

Invasive aspergillosis is a disease of the immunosuppressed patient. We describe two patients with acute lymphoblastic leukaemia who attained complete remission, with partial or complete bone marrow recovery, but who went on to develop fatal invasive aspergillosis contemporaneous with recovery of neutrophil counts. Quantitative recovery of peripheral blood neutrophil counts does not guarantee control of Aspergillus infection, perhaps due to functional neutrophil deficiencies post-chemotherapy, and specific defensive strategies adopted by the organism itself.

摘要

侵袭性曲霉病是免疫抑制患者易患的疾病。我们描述了两名急性淋巴细胞白血病患者，他们达到了完全缓解，骨髓部分或完全恢复，但在中性粒细胞计数恢复的同时却发生了致命的侵袭性曲霉病。外周血中性粒细胞计数的定量恢复并不能保证对曲霉菌感染的控制，这可能是由于化疗后中性粒细胞功能缺陷以及病原体自身采取的特定防御策略所致。

相似文献

1

Invasive aspergillosis in two patients with acute lymphoblastic leukaemia in complete remission.两名急性淋巴细胞白血病完全缓解患者发生侵袭性曲霉病。

Postgrad Med J. 1993 May;69(811):405-8. doi: 10.1136/pgmj.69.811.405.

2

Complicated pulmonary aspergillosis with pneumothorax and pneumopericardium in a child with acute lymphoblastic leukemia.一名急性淋巴细胞白血病患儿并发肺曲霉病伴气胸和心包积气

Pediatr Hematol Oncol. 1995 Mar-Apr;12(2):195-9. doi: 10.3109/08880019509029555.

3

Renal infarction secondary to invasive aspergillosis in a 5-year-old girl with acute lymphoblastic leukemia.一名患有急性淋巴细胞白血病的5岁女孩因侵袭性曲霉病继发肾梗死。

J Pediatr Hematol Oncol. 2014 Jul;36(5):e296-8. doi: 10.1097/MPH.0000000000000010.

4

[Cutaneous hyalohyphomycosis in a patient with acute lymphoblastic leukemia].

Medicina (B Aires). 2012;72(6):481-3.

5

Palmar necrosis during the treatment of acute myeloid leukaemia.

Neth J Med. 2012 Dec;70(10):467, 472.

6

[Invasive bronchopulmonary aspergillosis treated with itraconazole in a patient with acute leukemia].[伊曲康唑治疗急性白血病患者侵袭性支气管肺曲霉病]

Sangre (Barc). 1993 Oct;38(5):399-402.

7

Invasive aspergillosis of the larynx in a child with acute lymphoblastic leukemia.

Pediatr Infect Dis J. 2005 Feb;24(2):190-1. doi: 10.1097/01.inf.0000153171.16525.28.

8

Disseminated aspergillosis in an adolescent with acute lymphoblastic leukemia.一名急性淋巴细胞白血病青少年患者的播散性曲霉病

Pediatr Blood Cancer. 2008 Sep;51(3):423-6. doi: 10.1002/pbc.21601.

9

Epidemiology of invasive aspergillosis and azole resistance in patients with acute leukaemia: the SEPIA Study.急性白血病患者侵袭性曲霉菌病和唑类耐药的流行病学：SEPIA 研究。

Int J Antimicrob Agents. 2017 Feb;49(2):218-223. doi: 10.1016/j.ijantimicag.2016.10.019. Epub 2016 Dec 12.

10

[Systemic infection of Aspergillus flavus in a patient with acute lymphoblastic leukemia].[一名急性淋巴细胞白血病患者的黄曲霉全身感染]

Rinsho Ketsueki. 2003 Oct;44(10):1026-31.

本文引用的文献

1

Phagocytic cell responses to Aspergillus fumigatus.

FEMS Microbiol Immunol. 1989 Apr;1(5):305-6. doi: 10.1111/j.1574-6968.1989.tb02401.x.

2

Killing of Aspergillus fumigatus spores by human lung macrophages: a paradoxical effect of heat-labile serum components.人肺巨噬细胞对烟曲霉孢子的杀伤作用：热不稳定血清成分的矛盾效应。

J Med Vet Mycol. 1989;27(5):295-302. doi: 10.1080/02681218980000401.

3

Fungal infections in the immunocompromised host.免疫功能低下宿主中的真菌感染。

Diagn Microbiol Infect Dis. 1989 Jul-Aug;12(4 Suppl):221S-228S. doi: 10.1016/0732-8893(89)90140-5.

4

Invasive aspergillosis: clinical and pathological features of a new animal model.

J Med Vet Mycol. 1989;27(1):5-15. doi: 10.1080/02681218980000021.

5

Incidence of nosocomial aspergillosis in patients with leukemia over a twenty-year period.

Infect Control Hosp Epidemiol. 1989 Jul;10(7):299-305. doi: 10.1086/646032.

6

Tissue destruction by neutrophils.中性粒细胞导致的组织破坏。

N Engl J Med. 1989 Feb 9;320(6):365-76. doi: 10.1056/NEJM198902093200606.

7

Aspergillosis.曲霉病

Eur J Clin Microbiol Infect Dis. 1989 May;8(5):413-37. doi: 10.1007/BF01964057.

8

Experimental murine invasive pulmonary aspergillosis.实验性小鼠侵袭性肺曲霉病

Am J Clin Pathol. 1990 Apr;93(4):510-5. doi: 10.1093/ajcp/93.4.510.

9

Disseminated aspergillosis in an apparently healthy patient.

Am J Med. 1990 Jan;88(1):74-6. doi: 10.1016/0002-9343(90)90132-w.

10

Antifungal and surgical treatment of invasive aspergillosis: review of 2,121 published cases.侵袭性曲霉病的抗真菌及手术治疗：2121例已发表病例综述

Rev Infect Dis. 1990 Nov-Dec;12(6):1147-201. doi: 10.1093/clinids/12.6.1147.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

文档翻译

学术文献翻译模型，支持多种主流文档格式。