Hansen M A, Overgaard K, Nielsen V A, Jensen G, Gotfredsen A, Christiansen C
Den Danske Forskningsfond, CCBR, Ballerup.
Ugeskr Laeger. 1993 Aug 2;155(31):2392-6.
We examined whether the prevalence of vertebral fracture in otherwise healthy, 70-year-old Danish women had increased over a period of ten years. The population-based, epidemiological study included two age-matched, representative samples of postmenopausal women. Group 1 (1979) consisted of 173 healthy women without secondary causes of osteoporosis, Group 2 (1989) of 387 women. X-rays of the thoraco-lumbar spine were assessed for vertebral fracture by five radiological methods. There was no significant difference between the two groups in the prevalence of vertebral fracture and the 95% confidence intervals overlapped completely in all methods. The prevalence rates varied by method from 35% to 80% but the distribution of fracture types was similar in the two groups. We conclude that the prevalence of vertebral fractures due to postmenopausal osteoporosis has not increased since 1979 in suburban Copenhagen, and that comparison of prevalences requires the same method of radiological assessment.
我们研究了在其他方面均健康的70岁丹麦女性中，椎骨骨折的患病率在十年间是否有所增加。这项基于人群的流行病学研究纳入了两组年龄匹配的绝经后女性代表性样本。第1组（1979年）由173名无骨质疏松继发原因的健康女性组成，第2组（1989年）由387名女性组成。采用五种放射学方法对胸腰椎X线片进行椎骨骨折评估。两组在椎骨骨折患病率方面无显著差异，且所有方法的95%置信区间完全重叠。不同方法的患病率从35%到80%不等，但两组骨折类型的分布相似。我们得出结论，自1979年以来，哥本哈根郊区绝经后骨质疏松所致椎骨骨折的患病率并未增加，且患病率的比较需要相同的放射学评估方法。
