Hansen M A, Overgaard K, Nielsen V A, Jensen G F, Gotfredsen A, Christiansen C
Department of Clinical Chemistry, Glostrup Hospital, University of Copenhagen, Denmark.
Osteoporos Int. 1992 Sep;2(5):241-6. doi: 10.1007/BF01624148.
We examined whether the prevalence of vertebral fractures in otherwise healthy, 70-year-old Danish women had increased during an interval of 10 years. The population-based epidemiological study included two age-matched groups of postmenopausal women. Group 1 consisted of 70-year-old women (n = 386) living in a defined area of suburban Copenhagen recruited in 1979 for an epidemiological study. Of the 285 women who were entered, 173 were judged healthy, without secondary causes of osteoporosis. Group 2 was recruited by sending questionnaires to all women aged 68-72 years living in the same area in 1989. Of the 512 women who attended a medical screening, 387 were found to be without secondary causes of osteoporosis and had a spinal radiograph. Radiographs of the thoracolumbar spine were assessed for vertebral fracture by five radiological methods. There was no significant difference between the two groups in the prevalence of vertebral fractures and the 95% confidence intervals overlapped completely in all methods. The prevalence rates varied by method from about 35% to more than 80% but the distribution of fracture types was similar in the two groups. We conclude that the prevalence of vertebral fractures due to postmenopausal osteoporosis has not increased since 1979 in otherwise healthy women residing in suburban Copenhagen, and that comparison of prevalences between studies requires that they use the same method of radiological assessment.
我们研究了在其他方面均健康的70岁丹麦女性中，椎体骨折的患病率在10年期间是否有所增加。这项基于人群的流行病学研究纳入了两组年龄匹配的绝经后女性。第1组由1979年在哥本哈根郊区特定区域招募的70岁女性（n = 386）组成，用于一项流行病学研究。在纳入研究的285名女性中，173名被判定为健康，无骨质疏松的继发原因。第2组是通过向1989年居住在同一地区的所有68 - 72岁女性发送问卷招募而来。在参加医学筛查的512名女性中，387名被发现无骨质疏松的继发原因并接受了脊柱X光检查。通过五种放射学方法对胸腰椎X光片进行椎体骨折评估。两组在椎体骨折患病率方面无显著差异，所有方法的95%置信区间完全重叠。患病率因方法不同而在约35%至超过80%之间变化，但两组骨折类型的分布相似。我们得出结论，自1979年以来，居住在哥本哈根郊区的其他方面均健康的女性中，绝经后骨质疏松所致椎体骨折的患病率并未增加，并且不同研究之间患病率的比较要求它们采用相同的放射学评估方法。
