Vuurman E F, van Veggel L M, Uiterwijk M M, Leutner D, O'Hanlon J F
Institute for Drugs, Safety and Behavior, University of Limburg, Maastricht, The Netherlands.
Ann Allergy. 1993 Aug;71(2):121-6.
Children suffering from seasonal allergic rhinitis and matched normals were instructed on the use of a didactic computer simulation in a realistic classroom situation. Groups of atopic children received different treatments before instruction; ie, sedating (diphenylhydramine HCl) or nonsedating (loratadine) antihistamines or placebo. All returned after 2 weeks for an examination measuring factual and conceptual knowledge and the application of a learned strategy. Examination results showed large and consistent impairing effects of the allergic reaction on prior learning. Both the placebo and diphenhydramine groups learned significantly less than normal controls. The loratadine group's learning performance was superior to either of the other atopic groups' but still inferior to the normals'. Our conclusions are that the allergic reaction reduces learning ability in children and that this effect is partially counteracted by treatment with loratadine and aggravated by diphenhydramine.
患有季节性过敏性鼻炎的儿童和匹配的正常儿童在真实的课堂环境中接受了关于使用教学计算机模拟的指导。特应性儿童组在指导前接受了不同的治疗；即，镇静（盐酸苯海拉明）或非镇静（氯雷他定）抗组胺药或安慰剂。两周后所有人返回进行检查，测量事实性和概念性知识以及所学策略的应用。检查结果显示，过敏反应对先前学习有显著且持续的损害作用。安慰剂组和苯海拉明组的学习明显少于正常对照组。氯雷他定组的学习表现优于其他任何一个特应性组，但仍低于正常组。我们的结论是，过敏反应会降低儿童的学习能力，这种影响部分被氯雷他定治疗抵消，而被苯海拉明加重。
