Elefteriades J A, Solomon L W, Salazar A M, Batsford W P, Baldwin J C, Kopf G S
Department of Diagnostic Imaging, Yale University School of Medicine, New Haven, Connecticut.
Ann Thorac Surg. 1993 Aug;56(2):242-50; discussion 251-2. doi: 10.1016/0003-4975(93)91154-f.
It remains uncertain whether left ventricular aneurysmectomy (LVA) improves ventricular function and whether LVA improves or distorts left ventricular contour. We applied the powerful imaging techniques of multiple-gated acquisition scanning, intraoperative transesophageal echocardiography, and magnetic resonance imaging to assess functional and morphologic changes after LVA in 75 consecutive patients undergoing LVA by conventional resection and linear closure. Fifty-two patients (69%) underwent concomitant coronary artery bypass grafting, 25 (33%) had directed endocardial resection, and 4 (5%) had valve replacement. The hospital mortality rate was 6.7% (5/75). Actuarial survival rates were 86%, 80%, and 64% at 1 year, 2 years, and 5 years, respectively. Mean anginal class improved from 3.49 to 1.24 (p < 0.0001). Mean congestive heart failure class improved from 3.04 to 1.70 (p < 0.0001). By multiple-gated acquisition scan (48 patients), mean ejection fraction improved from 0.25 preoperatively to 0.33 postoperatively (p < 0.0001). Intraoperative transesophageal echocardiography (28 patients) revealed no cases of distortion and demonstrated normalization of left ventricular contour in 69% of patients. Mean wall motion score improved from 16.4 to 18.8 (p < 0.001). Mean cross-sectional area of the left ventricle decreased from 18.7 cm2 to 12.8 cm2 (p < 0.006). Magnetic resonance imaging confirmed normalization of left ventricular contour without distortion. We conclude that linear LVA is clinically effective and objectively improves left ventricular morphology and function. On this basis, we have extended application of LVA to include patients with at least moderate-sized aneurysms undergoing coronary artery bypass grafting, despite the absence of traditional indications of arrhythmia, embolism, and frank congestive heart failure.
左心室动脉瘤切除术(LVA)是否能改善心室功能,以及LVA会改善还是扭曲左心室轮廓仍不确定。我们应用多门控采集扫描、术中经食管超声心动图和磁共振成像等强大的成像技术,对75例连续接受传统切除和线性闭合LVA手术的患者进行LVA术后功能和形态学变化评估。52例患者(69%)同时接受了冠状动脉搭桥术,25例(33%)进行了直接心内膜切除术,4例(5%)进行了瓣膜置换。医院死亡率为6.7%(5/75)。1年、2年和5年的精算生存率分别为86%、80%和64%。平均心绞痛分级从3.49改善至1.24(p<0.0001)。平均充血性心力衰竭分级从3.04改善至1.70(p<0.0001)。通过多门控采集扫描(48例患者),平均射血分数从术前的0.25提高到术后的0.33(p<0.0001)。术中经食管超声心动图(28例患者)显示无扭曲病例,69%的患者左心室轮廓恢复正常。平均壁运动评分从16.4提高到18.8(p<0.001)。左心室平均横截面积从18.7 cm²降至12.8 cm²(p<0.006)。磁共振成像证实左心室轮廓恢复正常且无扭曲。我们得出结论,线性LVA在临床上是有效的,并且客观上改善了左心室形态和功能。在此基础上,我们将LVA的应用范围扩大到包括至少患有中等大小动脉瘤且正在接受冠状动脉搭桥术的患者,尽管缺乏心律失常、栓塞和明显充血性心力衰竭等传统指征。