Matsui M, Takahashi M, Homma H
Kyoritsu College of Pharmacy, Tokyo, Japan.
Biochem Pharmacol. 1993 Aug 3;46(3):465-70. doi: 10.1016/0006-2952(93)90523-y.
Triethylamine, which was used as an elution solvent for column chromatography to purify chemically synthesized 3'-phosphoadenosine 5'-phosphosulfate (PAPS), was a potent inhibitor of rat liver sulfotransferase (ST) activities toward androsterone and dehydroepiandrosterone, but not ST activities toward cortisol and 2-naphthol. Examination of fourteen primary, secondary and tertiary amines revealed that a secondary amine, di-n-butylamine, and three tertiary amines, triethylamine, tri-n-propylamine and tri-n-butylamine, specifically inhibited ST activities toward androgen.
三乙胺用作柱色谱的洗脱溶剂来纯化化学合成的3'-磷酸腺苷5'-磷酸硫酸酯（PAPS），它是大鼠肝脏磺基转移酶（ST）催化雄甾酮和脱氢表雄酮反应活性的强效抑制剂，但对ST催化皮质醇和2-萘酚反应的活性没有抑制作用。对十四种伯胺、仲胺和叔胺进行研究后发现，仲胺二正丁胺以及三种叔胺三乙胺、三正丙胺和三正丁胺会特异性抑制ST催化雄激素反应的活性。
