Legrand E, Vincent M
CDTS Orléans, CHR.
Rev Fr Transfus Hemobiol. 1993 Jun;36(3):211-21. doi: 10.1016/s1140-4639(05)80182-0.
Since their creation, leukocyte depletion filters, used to prepare leukocyte-poor red cell or platelet concentrates, have been continuously evoluting: their volume has been reduced and their composition has been modified, polyester fibers have replaced cotton wool or cellulose acetate. In the same way, their capacity to remove leukocytes has increased. The mechanisms of cell separation are still unclear. Through published studies, different factors seem to be implicated, such as wetable surface of the filter, surface tension or charge density of fibers. It was also observed that removal of lymphocytes from red cell concentrates is rather based on trapping in the fiber network, and that removal of granulocytes, monocytes and platelets is partly due to activation and subsequent adhesion to the fibers. There have been few studies of the mechanism of leukocytes depletion from platelets concentrates.
自白细胞去除滤器发明以来，其一直用于制备少白细胞红细胞或血小板浓缩物，并不断发展：其体积减小，组成改变，聚酯纤维取代了棉绒或醋酸纤维素。同样，其去除白细胞的能力也有所提高。细胞分离的机制仍不清楚。通过已发表的研究，似乎涉及不同因素，如滤器的可湿润表面、纤维的表面张力或电荷密度。还观察到，从红细胞浓缩物中去除淋巴细胞主要基于截留在纤维网络中，而去除粒细胞、单核细胞和血小板部分是由于激活以及随后与纤维的粘附。关于从血小板浓缩物中去除白细胞的机制的研究很少。
