Sprent J
Department of Immunology, Scripps Research Institute, La Jolla, California 92037.
Curr Opin Immunol. 1993 Jun;5(3):433-8. doi: 10.1016/0952-7915(93)90065-z.
Typical T and B lymphocytes in the secondary lymphoid organs are long-lived cells that are selected from a large pool of short-lived precursor cells in the primary lymphoid organs. The bulk of mature T and B cells are immunologically naive and remain in interphase for prolonged periods. Contact with specific antigen causes these naive cells to proliferate rapidly and differentiate into a mixture of short-lived effector cells and long-lived memory cells. Memory cells have a rapid turnover, and the survival of these cells appears to require persistent contact with antigen.
次级淋巴器官中的典型T淋巴细胞和B淋巴细胞是长寿细胞，它们从初级淋巴器官中的大量短命前体细胞中筛选出来。大多数成熟的T细胞和B细胞在免疫上是未致敏的，并长期处于间期。与特定抗原接触会使这些未致敏细胞迅速增殖，并分化为短命效应细胞和长寿记忆细胞的混合物。记忆细胞更新迅速，这些细胞的存活似乎需要与抗原持续接触。
