Tough D F, Sprent J
Department of Immunology, IMM4, Scripps Research Institute, La Jolla, CA 92037, USA.
Immunol Res. 1995;14(1):1-12. doi: 10.1007/BF02918494.
T and B lymphocytes comprise heterogeneous populations of cells at various stages of differentiation and activation. T- and B-cell subsets have different roles in the maintenance of immune homeostasis, and their functional differences are reflected by their respective lifespans. This review briefly summarizes the available data on lymphocyte lifespan, including the kinetics of T- and B-cell development in the primary lymphoid organs and the proliferative behavior of naive, effector and memory lymphocytes in the peripheral lymphoid compartment.
T淋巴细胞和B淋巴细胞由处于不同分化和激活阶段的异质性细胞群体组成。T细胞亚群和B细胞亚群在维持免疫稳态中发挥不同作用，它们的功能差异通过各自的寿命得以体现。本综述简要总结了关于淋巴细胞寿命的现有数据，包括初级淋巴器官中T细胞和B细胞发育的动力学，以及外周淋巴区室中初始、效应和记忆淋巴细胞的增殖行为。
