A pilot clinical trial of the angiotensin-converting enzyme inhibitor ceranapril in Alzheimer disease.

作者信息

Sudilovsky A, Cutler N R, Sramek J J, Wardle T, Veroff A E, Mickelson W, Markowitz J, Repetti S

机构信息

Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey.

出版信息

Alzheimer Dis Assoc Disord. 1993 Summer;7(2):105-11. doi: 10.1097/00002093-199307020-00006.

This pilot clinical trial was a 15-week, double-blind, controlled, three-way crossover study evaluating cognitive effects of ceranapril in subjects with dementia of the Alzheimer type (age range 50-75 years). Computerized (CNTB) and noncomputerized cognitive test batteries revealed no significant results (p > 0.05). On further analysis of the data, however, a study of longer duration and/or higher dosages may be warranted.