血管紧张素转换酶抑制剂西拉普利治疗阿尔茨海默病的一项试点临床试验。
A pilot clinical trial of the angiotensin-converting enzyme inhibitor ceranapril in Alzheimer disease.
作者信息
Sudilovsky A, Cutler N R, Sramek J J, Wardle T, Veroff A E, Mickelson W, Markowitz J, Repetti S
机构信息
Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey.
出版信息
Alzheimer Dis Assoc Disord. 1993 Summer;7(2):105-11. doi: 10.1097/00002093-199307020-00006.
This pilot clinical trial was a 15-week, double-blind, controlled, three-way crossover study evaluating cognitive effects of ceranapril in subjects with dementia of the Alzheimer type (age range 50-75 years). Computerized (CNTB) and noncomputerized cognitive test batteries revealed no significant results (p > 0.05). On further analysis of the data, however, a study of longer duration and/or higher dosages may be warranted.
这项试点临床试验是一项为期15周的双盲、对照、三向交叉研究，评估了西拉普利对阿尔茨海默型痴呆患者（年龄范围50-75岁）认知功能的影响。计算机化（CNTB）和非计算机化认知测试组均未得出显著结果（p>0.05）。然而，在对数据进行进一步分析后，可能需要进行持续时间更长和/或剂量更高的研究。
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