在转化生长因子-β刺激AKR-2B细胞后，碱性成纤维细胞生长因子（bFGF）基因表达增强。
Enhanced bFGF gene expression in response to transforming growth factor-beta stimulation of AKR-2B cells.
作者信息
Pertovaara L, Saksela O, Alitalo K
机构信息
Department of Pathology, University of Helsinki, Finland.
出版信息
Growth Factors. 1993;9(1):81-6. doi: 10.3109/08977199308991584.
PMID:8347352
Abstract
Treatment of quiescent cultures of mouse embryo-derived AKR-2B cells with transforming growth factor beta resulted in an induction of basic fibroblast growth factor (bFGF) mRNA and bFGF protein in the stimulated cells. In contrast to bFGF, acidic fibroblast growth factor (aFGF) was not induced by TGF beta. The mitogenic effect of transforming growth factor beta on AKR-2B cells may be mediated by the induction of bFCF in these cells.
摘要
用转化生长因子β处理源自小鼠胚胎的静止AKR - 2B细胞培养物，会导致受刺激细胞中碱性成纤维细胞生长因子（bFGF）mRNA和bFGF蛋白的诱导。与bFGF相反，酸性成纤维细胞生长因子（aFGF）不会被TGFβ诱导。转化生长因子β对AKR - 2B细胞的促有丝分裂作用可能是由这些细胞中bFCF的诱导介导的。
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